Technology Process of 2,3,3aβ,5,6,7,8,8a,9,9aβ-decahydro-8aβ-methyl-2-oxo-5β-(phenylthio)naphtho<2,3-b>furan-3-carboxylic acid methyl ester
There total 9 articles about 2,3,3aβ,5,6,7,8,8a,9,9aβ-decahydro-8aβ-methyl-2-oxo-5β-(phenylthio)naphtho<2,3-b>furan-3-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
74064-09-8
2,3,3aβ,5,6,7,8,8a,9,9aβ-decahydro-8aβ-methyl-2-oxo-5β-(phenylthio)naphtho<2,3-b>furan-3-carboxylic acid methyl ester
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile);
In
benzene;
at 60 ℃;
for 20h;
Yield given;
DOI:10.1021/ja00527a046
-
-
74064-09-8
2,3,3aβ,5,6,7,8,8a,9,9aβ-decahydro-8aβ-methyl-2-oxo-5β-(phenylthio)naphtho<2,3-b>furan-3-carboxylic acid methyl ester
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 50 percent / titanium tetrachloride / CH2Cl2 / 0.07 h / -78 °C
2: 93 percent / anhydrous potassium carbonate / methanol; H2O / 14 h / Ambient temperature
3: 65 percent / sodium acetate, acetic anhydride / 8 h / 105 °C
4: 1.) N-bromosuccinimide / 1.) carbon tetrachloride, 85 deg C, 2.) irradiation, reflux, 20 min
5: 97 percent / sodium cyanoborohydride, 1N ethanolic hydrogen chloride / tetrahydrofuran / 1 h / Ambient temperature
6: 95 percent / 1,5-diazabicyclo<4.3.0>non-2-ene / benzene / 1.25 h / Ambient temperature
7: 2,2'-azobisisobutyronitrile / benzene / 20 h / 60 °C
With
hydrogenchloride; N-Bromosuccinimide; 1,5-diazabicyclo[4.3.0]-non-2-ene; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic anhydride; titanium tetrachloride; sodium cyanoborohydride; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1021/ja00527a046
-
-
74064-09-8
2,3,3aβ,5,6,7,8,8a,9,9aβ-decahydro-8aβ-methyl-2-oxo-5β-(phenylthio)naphtho<2,3-b>furan-3-carboxylic acid methyl ester
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / phosphorus pentoxide, methanesulphonic acid / 1.5 h / Ambient temperature
2: 50 percent / titanium tetrachloride / CH2Cl2 / 0.07 h / -78 °C
3: 93 percent / anhydrous potassium carbonate / methanol; H2O / 14 h / Ambient temperature
4: 65 percent / sodium acetate, acetic anhydride / 8 h / 105 °C
5: 1.) N-bromosuccinimide / 1.) carbon tetrachloride, 85 deg C, 2.) irradiation, reflux, 20 min
6: 97 percent / sodium cyanoborohydride, 1N ethanolic hydrogen chloride / tetrahydrofuran / 1 h / Ambient temperature
7: 95 percent / 1,5-diazabicyclo<4.3.0>non-2-ene / benzene / 1.25 h / Ambient temperature
8: 2,2'-azobisisobutyronitrile / benzene / 20 h / 60 °C
With
hydrogenchloride; phosphorus pentaoxide; N-Bromosuccinimide; 1,5-diazabicyclo[4.3.0]-non-2-ene; methanesulfonic acid; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic anhydride; titanium tetrachloride; sodium cyanoborohydride; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1021/ja00527a046
