N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

Base Information

Chemical Name:N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester
CAS No.:847934-53-6
Molecular Formula:C₅₆H₇₈N₄O₁₂P₂
Molecular Weight:1061.2
Hs Code.:

<i>N</i>-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-<i>tert</i>-butoxy-phosphorylmethyl)-benzyl]-succinamic acid <i>tert</i>-butyl ester

Synonyms:N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

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Chemical Property of N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

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Technology Process of N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

There total 4 articles about N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 491831-48-2
2-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinic acid 4-tert-butyl ester

: {(S)-6-Amino-6-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-5,6,7,8-tetrahydro-naphthalen-2-yl}-phosphonic acid diethyl ester

: 847934-53-6
N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0492709

Reference yield:

: 284677-41-4
(S)-asparagine-3-((1-naphthyl)propyl)amide

: 847934-53-6
N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 32 percent / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

2: trifluoroacetic acid; anisole / 20 °C

3: 64 mg / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

With methoxybenzene; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm0492709

Reference yield:

: 690254-51-4
(S)-2-(tert-butyloxycarbonyl)amino-1,2,3,4-tetrahydro-6-(diethylphosphono)-2-naphthalenecarboxylic acid

: 847934-53-6
N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 32 percent / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

2: trifluoroacetic acid; anisole / 20 °C

3: 64 mg / tetramethylfluoroformamidinium hexafluorophosphate; i-Pr₂NEt / dimethylformamide / 20 °C

With methoxybenzene; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm0492709