2,2'-BIPYRIDINE-4,4'-DICARBONITRILE

Base Information

• Chemical Name: 2,2'-BIPYRIDINE-4,4'-DICARBONITRILE
• CAS No.: 727380-18-9
• Molecular Formula: C₁₂H₁₄N₄
• Molecular Weight: 214.27
• Mol file: 727380-18-9.mol

Synonyms:4,4'-bis(aminomethyl)-2,2'-bipyridine

Chemical Property of 2,2'-BIPYRIDINE-4,4'-DICARBONITRILE

Chemical Property:

Purity/Quality:

99.0% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-BIPYRIDINE-4,4'-DICARBONITRILE

There total 6 articles about 2,2'-BIPYRIDINE-4,4'-DICARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,4'-bis(bromomethyl)-2,2'-bipyridine (134457-14-0,134457-15-1) → 4,4'-bis(aminomethyl)-2,2'-bipyridine (727380-18-9)

Guidance literature:

4,4'-bis(bromomethyl)-2,2'-bipyridine; With potassium phtalimide; In N,N-dimethyl-formamide;

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.tetasy.2013.03.014

Reference yield: 96.0%

4,4'-bis(azidomethylene)-2,2-bipyridine → 4,4'-bis(aminomethyl)-2,2'-bipyridine (727380-18-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; for 48h; Inert atmosphere;

Reference yield:

4,4'-dimethyl-2,2'-bipyridines (1134-35-6) → 4,4'-bis(aminomethyl)-2,2'-bipyridine (727380-18-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium permanganate; sulfuric acid / 24 h / Reflux

2: sulfuric acid / Reflux

3: sodium tetrahydroborate / ethanol / Reflux

4: hydrogen bromide / Reflux

5: potassium phtalimide / N,N-dimethyl-formamide

With sodium tetrahydroborate; potassium permanganate; sulfuric acid; hydrogen bromide; potassium phtalimide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2013.03.014

upstream raw materials:

4,4'-bis(bromomethyl)-2,2'-bipyridine

4,4'-dimethyl-2,2'-bipyridines

2,2'-Bipyridine-4,4'-dicarboxylic acid

4,4'-bis(carbomethoxy)-2,2'-bipyridine

Downstream raw materials:

1,1'-([2,2'-bipyridine]-4,4'-diylbis(methylene))bis(3-(3,5-bis(triflu-oromethyl)phenyl)-thiourea)