methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate

Base Information

Chemical Name:methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate
CAS No.:1597575-44-4
Molecular Formula:C₂HF₃O₂*C₂₆H₃₂N₄O₄
Molecular Weight:578.588
Hs Code.:

Synonyms:methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate

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Chemical Property of methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate

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Technology Process of methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate

There total 6 articles about methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

: 1430217-39-2
(S)-methyl 4-(1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate

: 27687-14-5
trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

: 76-05-1
trifluoroacetic acid

: 1597575-44-4
methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate

Guidance literature:: (S)-methyl 4-(1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate; trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; for 24h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 1597575-44-4
methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 24 h / 0 °C

2: zinc; ammonium chloride / water; acetone / 24 h / Cooling with ice

3: hydrogenchloride / 1,4-dioxane; diethyl ether / 0.25 h

4: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethyl acetate / 24 h

5: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 24 h

6: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 24 h

With pyridine; hydrogenchloride; tetrabutyl ammonium fluoride; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1430217-38-1
(S)-(9H-fluoren-9-yl)methyl 1-((4-((methoxycarbonyl)amino)phenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1597575-44-4
methyl 4-(2-((1r,4r)-4-(aminomethyl)cyclohexanecarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)phenylcarbamate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 24 h

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 24 h

With tetrabutyl ammonium fluoride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In N,N-dimethyl-formamide;