2-Cyclopentene-1-carboxylicacid,4-(acetylamino)-,ethylester,(1R,4S)-rel-

Base Information

• Chemical Name: 2-Cyclopentene-1-carboxylicacid,4-(acetylamino)-,ethylester,(1R,4S)-rel-
• CAS No.: 155755-47-8
• Molecular Formula: C₁₀H₁₅NO₃
• Molecular Weight: 197.234
• Mol file: 155755-47-8.mol

Synonyms:2-Cyclopentene-1-carboxylicacid, 4-(acetylamino)-, ethyl ester, cis-(?à)-; 2-Cyclopentene-1-carboxylic acid,4-(acetylamino)-, ethyl ester, cis-

Chemical Property of 2-Cyclopentene-1-carboxylicacid,4-(acetylamino)-,ethylester,(1R,4S)-rel-

Chemical Property:

• Boiling Point: 349.5±42.0 °C(Predicted)
• PKA: 15.35±0.40(Predicted)
• Density: 1.10±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyclopentene-1-carboxylicacid,4-(acetylamino)-,ethylester,(1R,4S)-rel-

There total 3 articles about 2-Cyclopentene-1-carboxylicacid,4-(acetylamino)-,ethylester,(1R,4S)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-4-amino-cyclopent-2-ene-1-carboxylic acid (102579-71-5,102579-72-6,102679-78-7,134003-04-6,134234-04-1) → (+/-)-ethyl (1SR,4RS)-4-acetamido-cyclopent-2-ene carboxylate (155755-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) SOCl₂ / 1.) a) 0 deg C, 90 min, b) RT, overnight

2: pyridine / 2 h / Ambient temperature

With pyridine; thionyl chloride;

DOI:10.1016/S0957-4166(00)86183-2

Reference yield:

2-azabicyclo[2.2.1.]hept-5-en-3-one (49805-30-3) → (+/-)-ethyl (1SR,4RS)-4-acetamido-cyclopent-2-ene carboxylate (155755-47-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 5percent aq. HCl / 24 h / Ambient temperature

2: 1.) SOCl₂ / 1.) a) 0 deg C, 90 min, b) RT, overnight

3: pyridine / 2 h / Ambient temperature

With pyridine; hydrogenchloride; thionyl chloride;

DOI:10.1016/S0957-4166(00)86183-2

Reference yield:

acetic anhydride (108-24-7) + (1S,4R)-4-Amino-cyclopent-2-enecarboxylic acid ethyl ester (733727-05-4) → (+/-)-ethyl (1SR,4RS)-4-acetamido-cyclopent-2-ene carboxylate (155755-47-8)

Guidance literature:

With pyridine; for 2h; Yield given; Ambient temperature;

DOI:10.1016/S0957-4166(00)86183-2

upstream raw materials:

acetic anhydride

(1S,4R)-4-Amino-cyclopent-2-enecarboxylic acid ethyl ester

cis-4-amino-cyclopent-2-ene-1-carboxylic acid

2-azabicyclo[2.2.1.]hept-5-en-3-one