2-Cyclopentene-1-carboxylicacid,4-amino-,ethylester,(1R,4S)-rel-(9CI)

Base Information

• Chemical Name: 2-Cyclopentene-1-carboxylicacid,4-amino-,ethylester,(1R,4S)-rel-(9CI)
• CAS No.: 733727-05-4
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.197
• Mol file: 733727-05-4.mol

Synonyms:2-Cyclopentene-1-carboxylicacid,4-amino-,ethylester,(1R,4S)-rel-(9CI)

Chemical Property of 2-Cyclopentene-1-carboxylicacid,4-amino-,ethylester,(1R,4S)-rel-(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyclopentene-1-carboxylicacid,4-amino-,ethylester,(1R,4S)-rel-(9CI)

There total 3 articles about 2-Cyclopentene-1-carboxylicacid,4-amino-,ethylester,(1R,4S)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + cis-4-amino-cyclopent-2-ene-1-carboxylic acid (102579-71-5,102579-72-6,102679-78-7,134003-04-6,134234-04-1) → (1S,4R)-4-Amino-cyclopent-2-enecarboxylic acid ethyl ester (733727-05-4)

Guidance literature:

With thionyl chloride; Multistep reaction; 1.) a) 0 deg C, 90 min, b) RT, overnight;

DOI:10.1016/S0957-4166(00)86183-2

Reference yield:

2-azabicyclo[2.2.1.]hept-5-en-3-one (49805-30-3) → (1S,4R)-4-Amino-cyclopent-2-enecarboxylic acid ethyl ester (733727-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 5percent aq. HCl / 24 h / Ambient temperature

2: 1.) SOCl₂ / 1.) a) 0 deg C, 90 min, b) RT, overnight

With hydrogenchloride; thionyl chloride;

DOI:10.1016/S0957-4166(00)86183-2

Reference yield:

racemic 2-azabicyclo[2.2.1]hept-5-en-3-one (49805-30-3) → (1S,4R)-4-Amino-cyclopent-2-enecarboxylic acid ethyl ester (733727-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: water; hydrogenchloride

2: sulfuryl dichloride / 3 h / Heating

With hydrogenchloride; sulfuryl dichloride; water;

DOI:10.1080/00397911.2020.1733612

upstream raw materials:

ethanol

cis-4-amino-cyclopent-2-ene-1-carboxylic acid

2-azabicyclo[2.2.1.]hept-5-en-3-one

racemic 2-azabicyclo[2.2.1]hept-5-en-3-one