4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide
• CAS No.: 1311184-71-0
• Molecular Formula: C₂₁H₂₃NO₂S
• Molecular Weight: 353.485
• Mol file: 1311184-71-0.mol

Synonyms:4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide

Chemical Property of 4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide

There total 8 articles about 4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-N-prop-2-ynylbenzenesulfonamide (55022-46-3) → 4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide (1311184-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 21 h / 0 °C / Reflux

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 16 h / 50 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In acetone;

DOI:10.1002/chem.201303025

Reference yield:

4-tolyl iodide (624-31-7) + 4-methyl-N-(2-methylallyl)-N-(prop-2-ynyl)benzenesulfonamide (132330-45-1) → 4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide (1311184-71-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 50 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201303025

Reference yield:

N-(2-methylallyl)-4-toluenesulfonamide (1206-41-3) + 4-(3-bromoprop-1-ynyl)toluene (130024-90-7) → 4-methyl-N-(2-methylallyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide (1311184-71-0)

Guidance literature:

4-(3-bromoprop-1-ynyl)toluene; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

N-(2-methylallyl)-4-toluenesulfonamide; In tetrahydrofuran;

DOI:10.1021/jo402550e

upstream raw materials:

4-methyl-N-prop-2-ynylbenzenesulfonamide

4-tolyl iodide

4-methyl-N-(2-methylallyl)-N-(prop-2-ynyl)benzenesulfonamide

toluene-4-sulfonamide

Downstream raw materials:

4-methyl-N-((2-methyloxiran-2-yl)methyl)-N-(3-(p-tolyl)prop-2-yn-1-yl)benzenesulfonamide

(5-methyl-1-tosyl-3,4-dehydropiperidin-3-yl)(p-tolyl)methanone

C₂₃H₂₉NO₂SSi