4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Base Information

• Chemical Name: 4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride
• CAS No.: 1456621-42-3
• Molecular Formula: C₂₁H₂₂Cl₂N₄O₃*ClH
• Molecular Weight: 485.798
• Mol file: 1456621-42-3.mol

Synonyms:4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Chemical Property of 4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

There total 8 articles about 4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.5%

N1,N1-bis(2-chloroethyl)benzene-1,2-diamine (13686-21-0) + 6-acetoxy-4-chloro-7-methoxyquinazoline (230955-75-6) → 4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride (1456621-42-3)

Guidance literature:

In isopropyl alcohol; for 0.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

ethyl 2-nitro-4,5-dimethoxybenzoate (100905-33-7) → 4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride (1456621-42-3)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogen; palladium on activated charcoal / methanol

2: 165 - 170 °C

3: L-methionine / methanesulfonic acid / 120 °C

4: dmap / pyridine

5: trichlorophosphate / toluene / Reflux

6: isopropyl alcohol / 0.5 h / Inert atmosphere; Reflux

With dmap; L-methionine; palladium on activated charcoal; hydrogen; trichlorophosphate; In pyridine; methanol; methanesulfonic acid; isopropyl alcohol; toluene;

DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

ethyl veratrate (3943-77-9) → 4-(2-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride (1456621-42-3)

Guidance literature:

Multi-step reaction with 7 steps

1: acetic acid; nitric acid / 0 °C

2: hydrogen; palladium on activated charcoal / methanol

3: 165 - 170 °C

4: L-methionine / methanesulfonic acid / 120 °C

5: dmap / pyridine

6: trichlorophosphate / toluene / Reflux

7: isopropyl alcohol / 0.5 h / Inert atmosphere; Reflux

With dmap; L-methionine; palladium on activated charcoal; hydrogen; nitric acid; acetic acid; trichlorophosphate; In pyridine; methanol; methanesulfonic acid; isopropyl alcohol; toluene;

DOI:10.1016/j.ejmech.2013.06.055

upstream raw materials:

N¹,N¹-bis(2-chloroethyl)benzene-1,2-diamine

6-acetoxy-4-chloro-7-methoxyquinazoline

ethyl veratrate

ethyl 2-nitro-4,5-dimethoxybenzoate