3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

• Chemical Name: 3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
• CAS No.: 760197-69-1
• Molecular Formula: C₂₇H₃₂O₃
• Molecular Weight: 404.549
• Mol file: 760197-69-1.mol

Synonyms:3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Chemical Property of 3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 1 articles about 3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,3-Dimethylacryloyl chloride (3350-78-5) + exo-10,10-diphenyl-10-hydroxymethyl-7,7-dimethylbicyclo[2.2.1]heptane-2-ol (221099-71-4) → 3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (760197-69-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetasy.2008.02.028

Reference yield:

3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (760197-69-1) → (R)-3,3-Dimethyl-oxirane-2-carboxylic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester + (S)-3,3-Dimethyl-oxirane-2-carboxylic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:

With Oxone; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate; In water; acetonitrile; at 0 ℃; for 2h;

DOI:10.1016/j.tet.2004.05.095

Reference yield:

N-aminophthalamide (1875-48-5) + 3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (760197-69-1) → (2S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethylaziridine-2-carboxylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester (1030379-40-8) + (2R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethylaziridine-2-carboxylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:

With lead(IV) acetate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1016/j.tetasy.2008.02.028

upstream raw materials:

3,3-Dimethylacryloyl chloride

exo-10,10-diphenyl-10-hydroxymethyl-7,7-dimethylbicyclo[2.2.1]heptane-2-ol

Downstream raw materials:

(2S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethylaziridine-2-carboxylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester