(2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

Base Information

Chemical Name:(2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol
CAS No.:883628-40-8
Molecular Formula:C₃₂H₃₄F₂N₂O₂
Molecular Weight:516.631
Hs Code.:

Synonyms:(2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

Suppliers and Price of (2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

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Chemical Property of (2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

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Technology Process of (2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

There total 1 articles about (2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 883440-68-4
(R)-4-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 883628-40-8
(2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

Guidance literature:: (R)-4-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; for 3h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 76.7%

: 883628-40-8
(2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

: 14618-80-5
(R)-benzyl glycidol

: (2R,3R,4S)-3-benzyloxy-2-(3-benzyloxy-2-hydroxypropylamino)-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-(R)-ol

Guidance literature:: In ethanol; at 80 ℃; for 16h; Sealed tube;

Reference yield: 73.0%

: 883628-40-8
(2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol

: 100-52-7
benzaldehyde

: 3-benzylamino-4-(R)-benzyloxy-5-(S)-dibenzylamino-6-(3,5-difluorophenyl)-hexan-1-(R)-ol

Guidance literature:: (2R,3R,4S)-2-amino-3-benzyloxy-4-dibenzylamino-5-(3,5-difluorophenyl)-pentan-1-ol; benzaldehyde; With 4 A molecular sieve; magnesium sulfate; In tetrahydrofuran; at 20 ℃; for 1.5h;

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃;

With hydrogenchloride; In ethanol; water; for 0.0833333h;