5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Base Information

• Chemical Name: 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid
• CAS No.: 1245734-61-5
• Molecular Formula: C₃₁H₂₅ClN₂O₅
• Molecular Weight: 541.003
• Mol file: 1245734-61-5.mol

Synonyms:5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Chemical Property of 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

There total 7 articles about 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H27ClN2O5 → 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid (1245734-61-5)

Guidance literature:

With sodium hydroxide; In water; at 60 ℃; for 0.5h;

DOI:10.1124/jpet.115.227157

Reference yield:

4-chloro-aniline (106-47-8) → 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid (1245734-61-5)

Guidance literature:

Multi-step reaction with 6 steps

1: toluene / 12 h / Reflux; Dean-Stark

2: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 35 °C

3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 12 h / 80 °C

4: isopropylmagnesium chloride / tetrahydrofuran; methanol / -80 °C

5: manganese(IV) oxide / 60 °C

6: sodium hydroxide / water / 0.5 h / 60 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; isopropylmagnesium chloride; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; toluene; 3: |Buchwald-Hartwig Coupling / 4: |Grignard Reaction;

DOI:10.1124/jpet.115.227157

Reference yield:

5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbaldehyde (1245703-51-8) → 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid (1245734-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: isopropylmagnesium chloride / tetrahydrofuran; methanol / -80 °C

2: manganese(IV) oxide / 60 °C

3: sodium hydroxide / water / 0.5 h / 60 °C

With manganese(IV) oxide; isopropylmagnesium chloride; sodium hydroxide; In tetrahydrofuran; methanol; water; 1: |Grignard Reaction;

DOI:10.1124/jpet.115.227157

upstream raw materials:

4-chloro-N-(cyclopropylmethyl)aniline

4-chloro-aniline

5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbaldehyde