5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Base Information

Chemical Name:5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid
CAS No.:1245734-61-5
Molecular Formula:C₃₁H₂₅ClN₂O₅
Molecular Weight:541.003
Hs Code.:

Synonyms:5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

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Chemical Property of 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

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Technology Process of 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

There total 7 articles about 5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₂₇ClN₂O₅

: 1245734-61-5
5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Guidance literature:: With sodium hydroxide; In water; at 60 ℃; for 0.5h;
DOI:10.1124/jpet.115.227157

Reference yield:

: 106-47-8
4-chloro-aniline

: 1245734-61-5
5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 12 h / Reflux; Dean-Stark

2: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 35 °C

3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 12 h / 80 °C

4: isopropylmagnesium chloride / tetrahydrofuran; methanol / -80 °C

5: manganese(IV) oxide / 60 °C

6: sodium hydroxide / water / 0.5 h / 60 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; isopropylmagnesium chloride; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; toluene; 3: |Buchwald-Hartwig Coupling / 4: |Grignard Reaction;
DOI:10.1124/jpet.115.227157

Reference yield:

: 1245703-51-8
5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbaldehyde

: 1245734-61-5
5-(5-((4-chlorophenyl)(cyclopropylmethyl)amino)pyridine-2-carbonyl)-2-(4-methoxybenzoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: isopropylmagnesium chloride / tetrahydrofuran; methanol / -80 °C

2: manganese(IV) oxide / 60 °C

3: sodium hydroxide / water / 0.5 h / 60 °C

With manganese(IV) oxide; isopropylmagnesium chloride; sodium hydroxide; In tetrahydrofuran; methanol; water; 1: |Grignard Reaction;
DOI:10.1124/jpet.115.227157