1245703-51-8Relevant articles and documents
Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase
Kleinschmidt, Thea K.,Haraldsson, Martin,Basavarajappa, Devaraj,Lundeberg, Erik,Thulasingam, Madhuranayaki,Ekoff, Maria,Fauland, Alexander,Lehmann, Christoph,Kahnt, Astrid S.,Lindbom, Lennart,Haeggstr?m, Jesper Z.
, p. 108 - 116 (2015/09/28)
Cysteinyl leukotrienes (cys-LTs) are lipid mediators of inflammation. The enzyme catalyzing synthesis of cys-LTs, leukotriene C4 synthase (LTC4S), is considered an important drug target. Here we report the synthesis and characterization of thre
Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors
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Paragraph 0196, (2013/03/26)
There is provided compounds of formula I, wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given
BIS AROMATIC COMPOUNDS FOR USE AS LTC4 SYNTHASE INHIBITORS
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Page/Page column 78, (2011/10/05)
There is provided compounds of formula (I): wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
BIS AROMATIC COMPOUNDS FOR USE AS LCT4 SYNTHASE INHIBITORS
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Page/Page column 90, (2010/10/03)
There is provided compounds of formula I, wherein Y, ring A, Da, Db, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
