ethyl 4-(1-bromoethyl)benzoic acid

Base Information

• Chemical Name: ethyl 4-(1-bromoethyl)benzoic acid
• CAS No.: 221279-14-7
• Molecular Formula: C₁₁H₁₃BrO₂
• Molecular Weight: 257.127
• Mol file: 221279-14-7.mol

Synonyms:ethyl 4-(1-bromoethyl)benzoic acid

Chemical Property of ethyl 4-(1-bromoethyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(1-bromoethyl)benzoic acid

There total 2 articles about ethyl 4-(1-bromoethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethanol (64-17-5) + 4-(1-bromoethyl)-benzoic acid (113023-73-7) → ethyl 4-(1-bromoethyl)benzoic acid (221279-14-7)

Guidance literature:

With acetyl chloride; at 0 - 25 ℃;

DOI:10.1021/jo9917846

Reference yield:

ethyl ester of para-ethylbenzoic acid (36207-13-3) → ethyl 4-(1-bromoethyl)benzoic acid (221279-14-7)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; Reflux; Under light;

DOI:10.1016/j.bmcl.2009.04.079

Reference yield: 100.0%

4-ethylpiperazine (5308-25-8) + ethyl 4-(1-bromoethyl)benzoic acid (221279-14-7) → 4-(4-ethyl piperazin-1-ylmethyl)-benzoic acid ethyl ester (1044872-36-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

ethanol

4-(1-bromoethyl)-benzoic acid

ethyl ester of para-ethylbenzoic acid

Downstream raw materials:

ethyl 4-(1-phthalimido)ethylbenzoate

4-(1-aminoethyl)-3-nitrobenzoic acid ethyl ester

3-nitro-4-{1-[(pyridine-3-carbonyl)-amino]-ethyl}-benzoic acid

N-(ethyl 4-(1-amino)ethyl-3-nitrobenzoate)nicotinamide

Refernces

• 1、 Salerno,Magde,Patron. "Enzymatic synthesis of caged NADP cofactors: Aqueous NADP photorelease and optical properties". . p. 3971 - 3981. Retrieved 2007/10/03.