<2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide

Base Information

Chemical Name:<2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide
CAS No.:157220-45-6
Molecular Formula:C₂₀H₃₅NO₄Si
Molecular Weight:381.588
Hs Code.:

Synonyms:<2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide

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Chemical Property of <2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide

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Technology Process of <2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide

There total 4 articles about <2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 162255-08-5
(2S,3S)-4-(benzyloxy)-3-hydroxy-N-methoxy-N,2-dimethylbutanamide

: 157220-45-6
<2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 25 ℃; for 16h;
DOI:10.1021/ja00117a014

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 157220-45-6
<2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) dibutylboron triflate, triethylamine / 1.) CH₂Cl₂, 0 deg C, 2.) CH₂Cl₂, -78 -> 0 deg C

2: 99 percent / trimethylaluminum / tetrahydrofuran; toluene; CH₂Cl₂ / 1.5 h / 0 °C

3: 100 percent / imidazole / dimethylformamide / 5.5 h / 23 °C

With 1H-imidazole; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo9606113

Reference yield:

: 157318-10-0
(4S,5R)-3-((2S,3S)-4-Benzyloxy-3-hydroxy-2-methyl-butyryl)-4-methyl-5-phenyl-oxazolidin-2-one

: 157220-45-6
<2S,3S>-3-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N-methoxy>-N,2-dimethyl-4-phenylmethoxybutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / trimethylaluminum / tetrahydrofuran; toluene; CH₂Cl₂ / 1.5 h / 0 °C

2: 100 percent / imidazole / dimethylformamide / 5.5 h / 23 °C

With 1H-imidazole; trimethylaluminum; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo9606113