Technology Process of (5S,6R,7R,10aR)-6-hydroxy-5-(4-methoxybenzyl)tetrahydro-1H-7,10a-methanopyrrolo[1,2-a]azocine-3,8(2H,5H)-dione
There total 15 articles about (5S,6R,7R,10aR)-6-hydroxy-5-(4-methoxybenzyl)tetrahydro-1H-7,10a-methanopyrrolo[1,2-a]azocine-3,8(2H,5H)-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyrrolidine; acetic acid;
In
ethyl acetate;
at 0 - 20 ℃;
for 24h;
diastereoselective reaction;
DOI:10.1016/j.tetlet.2010.05.089
- Guidance literature:
-
Multi-step reaction with 13 steps
1.1: triethylamine; tert-butylmagnesium chloride / tetrahydrofuran / 0 - 20 °C
2.1: sodium tetrahydroborate / methanol / 20 °C
3.1: sodium hydroxide / tetrahydrofuran; water / 20 °C
4.1: potassium thioacyanate / water; ethanol / 24 h / 20 - 60 °C
4.2: 12 h / 80 °C
5.1: hydrogenchloride / methanol; water / 24 h / 20 °C
6.1: methanol / 20 °C
7.1: camphor-10-sulfonic acid; trimethyl orthoformate / 20 °C
8.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
9.1: sodium tetrahydroborate / methanol / 24 h / 20 °C
10.1: trichlorophosphate; pyridine / 2 h / 60 °C
11.1: methanol; magnesium / 5 h / Heating
11.2: 2 h / 0 - 20 °C
12.1: ozone; dimethylsulfide / methanol / -78 - 20 °C / Inert atmosphere
13.1: pyrrolidine; acetic acid / ethyl acetate / 24 h / 0 - 20 °C
With
pyrrolidine; pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; dimethylsulfide; camphor-10-sulfonic acid; tert-butylmagnesium chloride; potassium thioacyanate; ozone; magnesium; acetic acid; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; trimethyl orthoformate;
In
tetrahydrofuran; methanol; ethanol; water; ethyl acetate;
6.1: |Ugi Condensation / 8.1: |Dieckmann Condensation;
DOI:10.3987/COM-12-S(N)38
- Guidance literature:
-
Multi-step reaction with 14 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: triethylamine; tert-butylmagnesium chloride / tetrahydrofuran / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol / 20 °C
4.1: sodium hydroxide / tetrahydrofuran; water / 20 °C
5.1: potassium thioacyanate / water; ethanol / 24 h / 20 - 60 °C
5.2: 12 h / 80 °C
6.1: hydrogenchloride / methanol; water / 24 h / 20 °C
7.1: methanol / 20 °C
8.1: camphor-10-sulfonic acid; trimethyl orthoformate / 20 °C
9.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
10.1: sodium tetrahydroborate / methanol / 24 h / 20 °C
11.1: trichlorophosphate; pyridine / 2 h / 60 °C
12.1: methanol; magnesium / 5 h / Heating
12.2: 2 h / 0 - 20 °C
13.1: ozone; dimethylsulfide / methanol / -78 - 20 °C / Inert atmosphere
14.1: pyrrolidine; acetic acid / ethyl acetate / 24 h / 0 - 20 °C
With
pyrrolidine; pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; dimethylsulfide; camphor-10-sulfonic acid; tert-butylmagnesium chloride; potassium thioacyanate; potassium carbonate; ozone; magnesium; acetic acid; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; trimethyl orthoformate;
In
tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
7.1: |Ugi Condensation / 9.1: |Dieckmann Condensation;
DOI:10.3987/COM-12-S(N)38
![(2S)-2-(2,8-dioxo-1-azaspiro[4.5]dec-1-yl)-3-(4-methoxyphenyl)propanal](/Databaselist/images/loading.webp)
