oc-O-Methyl-L-TyrosineMethylEster

Base Information

• Chemical Name: oc-O-Methyl-L-TyrosineMethylEster
• CAS No.: 94790-24-6
• Molecular Formula: C16H23 N O5
• Molecular Weight: 309.362
• Hs Code.: 2924299090
• Mol file: 94790-24-6.mol

Synonyms:(L)-MethylN-(tert-butyloxycarbonyl)-4-methoxyphenylalaninate;(S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-methoxyphenyl)propionic acid methylester; N-tert-Butoxycarbonyl-O-methyl-L-tyrosine methyl ester

Chemical Property of oc-O-Methyl-L-TyrosineMethylEster

Chemical Property:

• PSA: 73.86000
• LogP: 2.69490

Purity/Quality:

98.5% ^*data from raw suppliers

Boc-Tyr(Me)-OMe 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of oc-O-Methyl-L-TyrosineMethylEster

There total 44 articles about oc-O-Methyl-L-TyrosineMethylEster which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) + methyl iodide (74-88-4) → (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate (94790-24-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2010.05.089

Reference yield: 97.0%

Boc-Tyr-OH (3978-80-1) + methyl iodide (74-88-4) → (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate (94790-24-6)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 25 ℃; for 3.5h;

DOI:10.1021/ja991160h

Reference yield: 97.0%

N-(tert-butoxycarbonyl)-D-tyrosine methyl ester (76757-90-9) + methyl iodide (74-88-4) → (2R)-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionic acid methyl ester (94790-24-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ol017016u

upstream raw materials:

di-tert-butyl dicarbonate

methyl (R)-2-amino-3-(4-methoxyphenyl)propanoate

N-(tert-butoxycarbonyl)-D-tyrosine methyl ester

dimethyl sulfate

Downstream raw materials:

(S )-methyl 2-((tert-butoxycarbonyl)amino)-3-(3-iodo-4-methoxyphenyl)propanoate

(R)-2-Dibenzylamino-3-(4-methoxy-phenyl)-propionaldehyde

(R)-2-Dibenzylamino-3-(4-methoxy-phenyl)-propan-1-ol

(R)-2-Dibenzylamino-3-(4-methoxy-phenyl)-propionic acid methyl ester

Refernces

• 1、 Agejas, Javier,Barberis, Mario,De Frutos, Oscar,Faraggi, Tomer M.,García-Cerrada, Susana,MacMillan, David W. C.,Mateos, Carlos,Rincón, Juan A.,Rouget-Virbel, Caroline. "Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis". . p. 1966 - 1973. Retrieved 2021/08/18.
• 2、 -. "BORYLATED AMINO ACID COMPOSITIONS FOR USE IN BORON NEUTRON CAPTURE THERAPY AND METHODS THEREOF". . . Retrieved 2020/09/19.