(S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

Base Information

Chemical Name:(S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one
CAS No.:122911-36-8
Molecular Formula:C₂₇H₃₈N₂O₇
Molecular Weight:502.608
Hs Code.:

Synonyms:(S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

Suppliers and Price of (S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

There total 11 articles about (S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128836-47-5
(2R,3R)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester

: 122911-36-8
(S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / NaH / dimethylformamide; tetrahydrofuran / 15 h / -3 °C

2: H₂ / 10percent Pd-C / ethanol / 2.5 h / 760 Torr / Ambient temperature

3: Isobutyric acid / toluene / 65 h / Heating

4: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

5: 89 percent / SO₃*Py, DMSO, NEt₃ / tetrahydrofuran / 0.25 h / Ambient temperature

6: 99.5 percent / CH₂Cl₂ / 48 h / Heating

7: 99 percent / H₂ / 10percent Pd-C / ethanol / 0.5 h / 760 Torr / Ambient temperature

8: LiOH / methanol; tetrahydrofuran; H₂O / 24 h / Ambient temperature

9: NEt₃ / toluene / 1.) -10 deg C, 10 min, 2.) 0 deg C, 40 min

10: 1.) BuLi / 1.) THF, hexane, 15 min, -75 deg C, 2.) toluene, 1 h, -75 deg C

11: 1.) NaN(SiMe₃)2, 2.) 2-benzenesulphonyl-3-phenyl-oxaziridine / 1.) THF, -78 deg C, 25 min, 2.) 20 min, -78 deg C

With lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; pyridine-SO₃ complex; hydrogen; sodium hexamethyldisilazane; sodium hydride; dimethyl sulfoxide; N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; palladium on activated charcoal; isobutyric Acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1039/P19900000047

Reference yield:

: 128836-48-6
(2R,3R)-3-(3-Amino-2,5-dimethoxy-phenyl)-3-methoxy-2-methyl-propionic acid methyl ester

: 122911-36-8
(S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: Isobutyric acid / toluene / 65 h / Heating

2: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

3: 89 percent / SO₃*Py, DMSO, NEt₃ / tetrahydrofuran / 0.25 h / Ambient temperature

4: 99.5 percent / CH₂Cl₂ / 48 h / Heating

5: 99 percent / H₂ / 10percent Pd-C / ethanol / 0.5 h / 760 Torr / Ambient temperature

6: LiOH / methanol; tetrahydrofuran; H₂O / 24 h / Ambient temperature

7: NEt₃ / toluene / 1.) -10 deg C, 10 min, 2.) 0 deg C, 40 min

8: 1.) BuLi / 1.) THF, hexane, 15 min, -75 deg C, 2.) toluene, 1 h, -75 deg C

9: 1.) NaN(SiMe₃)2, 2.) 2-benzenesulphonyl-3-phenyl-oxaziridine / 1.) THF, -78 deg C, 25 min, 2.) 20 min, -78 deg C

With lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; pyridine-SO₃ complex; hydrogen; sodium hexamethyldisilazane; dimethyl sulfoxide; N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; palladium on activated charcoal; isobutyric Acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1039/P19900000047

Reference yield:

: 122911-31-3
(2S,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propan-1-ol

: 122911-36-8
(S)-3-{(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoyl}-4-isopropyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / SO₃*Py, DMSO, NEt₃ / tetrahydrofuran / 0.25 h / Ambient temperature

2: 99.5 percent / CH₂Cl₂ / 48 h / Heating

3: 99 percent / H₂ / 10percent Pd-C / ethanol / 0.5 h / 760 Torr / Ambient temperature

4: LiOH / methanol; tetrahydrofuran; H₂O / 24 h / Ambient temperature

5: NEt₃ / toluene / 1.) -10 deg C, 10 min, 2.) 0 deg C, 40 min

6: 1.) BuLi / 1.) THF, hexane, 15 min, -75 deg C, 2.) toluene, 1 h, -75 deg C

7: 1.) NaN(SiMe₃)2, 2.) 2-benzenesulphonyl-3-phenyl-oxaziridine / 1.) THF, -78 deg C, 25 min, 2.) 20 min, -78 deg C

With lithium hydroxide; n-butyllithium; pyridine-SO₃ complex; hydrogen; sodium hexamethyldisilazane; dimethyl sulfoxide; N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1039/P19900000047