Technology Process of (2S,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propan-1-ol
There total 6 articles about (2S,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / H2 / 10percent Pd-C / ethanol / 2.5 h / 760 Torr
2: 91 percent / isobutyric acid / toluene / 65 h / Heating
3: 100 percent / LiAlH4 / tetrahydrofuran / 3 h / -5 °C
With
lithium aluminium tetrahydride; hydrogen; isobutyric Acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 16 h / -5 °C
2: 100 percent / H2 / 10percent Pd-C / ethanol / 2.5 h / 760 Torr
3: 91 percent / isobutyric acid / toluene / 65 h / Heating
4: 100 percent / LiAlH4 / tetrahydrofuran / 3 h / -5 °C
With
lithium aluminium tetrahydride; hydrogen; sodium hydride; isobutyric Acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Et2BOTf, Et3N / 1.) CH2Cl2, -2 deg C, 1 h, 2.) 0.5 h, -78 deg C; 1 h, 0 deg C
2: 97 percent / NaOMe / methanol; CH2Cl2 / 0.25 h / -17 °C
3: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 16 h / -5 °C
4: 100 percent / H2 / 10percent Pd-C / ethanol / 2.5 h / 760 Torr
5: 91 percent / isobutyric acid / toluene / 65 h / Heating
6: 100 percent / LiAlH4 / tetrahydrofuran / 3 h / -5 °C
With
lithium aluminium tetrahydride; hydrogen; sodium methylate; sodium hydride; triethylamine; isobutyric Acid; diethylboron trifluoromethanesulfonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
