3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid

Base Information

Chemical Name:3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid
CAS No.:80272-17-9
Molecular Formula:C₁₆H₁₁BrClF₃O₂
Molecular Weight:407.614
Hs Code.:

Synonyms:3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid

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Chemical Property of 3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid

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Technology Process of 3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid

There total 4 articles about 3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85118-24-7
2-bromo-4-(trifluoromethyl)benzaldehyde

: 80272-17-9
3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / piperidine / toluene / 0.5 h / Heating

2: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min

3: aq. H₂SO₄, CH₃COOH / 24 h / Heating

With piperidine; sulfuric acid; magnesium; acetic acid; In toluene;
DOI:10.1021/jm00361a002

Reference yield:

: 3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

: 80272-17-9
3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid

Guidance literature:: With sulfuric acid; acetic acid; for 24h; Yield given; Heating;
DOI:10.1021/jm00361a002

Reference yield:

: 106-39-8
bromochlorobenzene

: 80272-17-9
3-(2-Bromo-4-trifluoromethyl-phenyl)-3-(4-chloro-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min

2: aq. H₂SO₄, CH₃COOH / 24 h / Heating

With sulfuric acid; magnesium; acetic acid;
DOI:10.1021/jm00361a002