85118-24-7

Basic information

• Product Name: 2-bromo-4-(trifluoromethyl)benzaldehyde
• Synonyms: 2-bromo-4-(trifluoromethyl)benzaldehyde;Einecs 285-677-2;3-Bromo-4-formylbenzotrifluoride
• CAS NO: 85118-24-7
• Molecular Formula: C₈H₄BrF₃O
• Molecular Weight: 253.0159696
• EINECS: 285-677-2
• Mol File: 85118-24-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 230.0±40.0℃ (760 Torr)
• Flash Point: 92.9±27.3℃
• Appearance: /
• Density: 1.677±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0676mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-bromo-4-(trifluoromethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-(trifluoromethyl)benzaldehyde(85118-24-7)
• EPA Substance Registry System: 2-bromo-4-(trifluoromethyl)benzaldehyde(85118-24-7)

Safety Data

• Hazardous Substances Data: 85118-24-7(Hazardous Substances Data)

Usage

General Description

2-bromo-4-(trifluoromethyl)benzaldehyde is a chemical compound with the molecular formula C8H5BrF3O. It is a white to light yellow crystalline solid that is commonly used as a building block in organic synthesis. 2-bromo-4-(trifluoromethyl)benzaldehyde is a benzaldehyde derivative with a bromine atom at the 2 position and a trifluoromethyl group at the 4 position. It is often utilized as a reagent in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 2-bromo-4-(trifluoromethyl)benzaldehyde has been reported to exhibit antimicrobial and anti-inflammatory properties in certain studies.

InChI:InChI=1/C8H4BrF3O/c9-7-3-6(8(10,11)12)2-1-5(7)4-13/h1-4H

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 481075-58-5 2-bromo-1-iodo-4-(trifluoromethyl)benzene 
• 657-64-7 2-bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene 

Downstream Products

• 1159114-81-4 (E)-1,2-di(2-bromo-4-trifluoromethyl-phenyl)ethene 
• 1246965-76-3 C₁₀H₄BrClF₆ 
• 1620902-74-0 ethyl (2E)-3-(2-bromo-4-trifluoromethylphenyl)prop-2-enoate 
• 1620902-81-9 ethyl (2E)-3-(2-allyl-4-trifluoromethylphenyl)prop-2-enoate 
• 1620902-88-6 (2E)-3-(2-allyl-4-trifluoromethylphenyl)prop-2-en-1-ol 
• 402-09-5 2-bromo-4-trifluoromethyl-styrene 
• 954239-22-6 6-(trifluoromethyl)-1H-indazole 

Relevant articles and documents

Rationally improved chiral Bronsted acid for catalytic enantioselective allylboration of aldehydes with an expanded reagent scope

(Chemical Equation Presented) One of the most useful reactions in organic synthesis, the stereocontrolled addition of allylic metal reagents to carbonyl compounds, provides access to enantiomerically enriched homoallylic alcohols related to the acetate, propionate, and other oxygen-containing functionalities present in a large number of biologically active natural products and pharmaceutical drugs. In the search for an ideal carbonyl allylation methodology, the catalytic enantioselective allylboration presents numerous advantages such as a high chemo-, diastereo-, and enantiocontrol with stable and nontoxic pinacol allylic boronates. This article reports a rationally improved diol·SnCl4 complex as chiral protic acid catalyst, which provides unprecedented levels of enantioselectivity in the catalytic allylation, methallylation, crotylation, and 2-bromoallylation of aliphatic aldehydes. The new diol, p-F-Vivol (4b), enables a more active diol·SnCl4 catalyst that can compete more effectively with the background uncatalyzed allylboration. The usefulness of this optimized catalytic allylboration methodology was demonstrated with an efficient synthesis of the naturally occurring pyranone (+)-dodoneine and to the preparation of biologically important exomethylene-γ-lactones.