[((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid

Base Information

Chemical Name:[((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid
CAS No.:1261301-18-1
Molecular Formula:C₂₅H₃₆NO₆P
Molecular Weight:477.538
Hs Code.:

Synonyms:[((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid

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Chemical Property of [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid

Chemical Property:

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Technology Process of [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid

There total 7 articles about [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1261301-17-0
methyl[((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamant-1-yloxy)phosphoryl]acetate

: 1261301-18-1
[((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; optical yield given as %de;
DOI:10.1007/s00726-010-0561-z

Reference yield:

: 110-62-3
pentanal

: 1261301-18-1
[((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,4-dioxane / Reflux

2.1: hydrogen bromide / 6 h / Reflux

2.2: pH 6

3.1: sodium carbonate / 1,4-dioxane; water / 0 - 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice; Inert atmosphere

5.1: dichloromethane / 1 h / Cooling with ice

6.1: silver(l) oxide / chloroform / 2 h / Reflux

7.1: water; sodium hydroxide / methanol / 20 °C

With water; hydrogen bromide; sodium carbonate; triethylamine; sodium hydroxide; silver(l) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; 5.1: Arbuzov reaction;
DOI:10.1007/s00726-010-0561-z

Reference yield:

: 106019-41-4,118636-65-0
[1-[[(phenylmethoxy)carbonyl]amino]pentyl]phosphinic acid

: 1261301-18-1
[((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(adamatyloxy)phosphoryl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice; Inert atmosphere

2: dichloromethane / 1 h / Cooling with ice

3: silver(l) oxide / chloroform / 2 h / Reflux

4: water; sodium hydroxide / methanol / 20 °C

With water; triethylamine; sodium hydroxide; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; chloroform; 2: Arbuzov reaction;
DOI:10.1007/s00726-010-0561-z