methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate

Base Information

Chemical Name:methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate
CAS No.:1067680-07-2
Molecular Formula:C₁₆H₂₄NO₆P
Molecular Weight:357.343
Hs Code.:

Synonyms:methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate

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Chemical Property of methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate

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Technology Process of methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate

There total 6 articles about methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 106019-41-4,118636-65-0
[1-[[(phenylmethoxy)carbonyl]amino]pentyl]phosphinic acid

: 96-32-2
bromoacetic acid methyl ester

: 1067680-07-2
methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate

Guidance literature:: With chloro-trimethyl-silane; TEA; at 20 ℃;
DOI:10.1016/j.tetlet.2008.07.062

Reference yield:

: 110-62-3
pentanal

: 1067680-07-2
methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / Reflux

2.1: hydrogen bromide / 6 h / Reflux

2.2: pH 6

3.1: sodium carbonate / 1,4-dioxane; water / 0 - 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice; Inert atmosphere

5.1: dichloromethane / 1 h / Cooling with ice

With hydrogen bromide; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 5.1: Arbuzov reaction;
DOI:10.1007/s00726-010-0561-z

Reference yield:

: 106019-41-4,118636-65-0
[1-[[(phenylmethoxy)carbonyl]amino]pentyl]phosphinic acid

: 1067680-07-2
methyl [((R,S)-1-{[(benzyloxy)carbonyl]amino}pent-1-yl)(hydroxy)phosphoryl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h / Cooling with ice; Inert atmosphere

2: dichloromethane / 1 h / Cooling with ice

With triethylamine; In tetrahydrofuran; dichloromethane; 2: Arbuzov reaction;
DOI:10.1007/s00726-010-0561-z