Technology Process of (+/-)-4-(1,7-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one
There total 11 articles about (+/-)-4-(1,7-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 1h;
under 750.075 Torr;
DOI:10.1016/j.bmc.2010.09.026
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 62 h / Reflux
2: hydrogenchloride / water; diethyl ether / 16 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 750.08 Torr
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
methanol; diethyl ether; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydroxide; water / ethanol / 5 h / Reflux
2.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere
3.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux
3.2: 1 h / Cooling with ice
4.1: potassium carbonate / acetone / 4 h / Reflux
5.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
6.1: methanol; magnesium / 5 h / Reflux
7.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 62 h / Reflux
8.1: hydrogenchloride / water; diethyl ether / 16 h / 20 °C
9.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 750.08 Torr
With
hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; palladium 10% on activated carbon; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; sodium hydroxide;
In
methanol; diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; acetonitrile;
