(+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

Base Information

Chemical Name:(+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one
CAS No.:1253197-49-7
Molecular Formula:C₂₇H₂₈FNO₃
Molecular Weight:433.523
Hs Code.:

Synonyms:(+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

Suppliers and Price of (+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

There total 10 articles about (+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1253197-33-9
(+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-49-7
(+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

Guidance literature:: (+/-)-7-(benzyloxy)-3-(3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol; With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In diethyl ether; water;
DOI:10.1016/j.bmc.2010.09.026

Reference yield:

: 1253197-26-0
(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-49-7
(+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 62 h / Reflux

2: hydrogenchloride / water; diethyl ether / 16 h / 20 °C

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; In diethyl ether; water; acetonitrile;

Reference yield:

: ethyl 2-{N-[2-(3-methoxyphenyl)ethyl]4-methylbenzenesulfonamido}acetate

: 1253197-49-7
(+/-)-4-(7-benzyloxy-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)-1-(4-fluorophenyl)butan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; water / ethanol / 5 h / Reflux

2.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

3.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

3.2: 1 h / Cooling with ice

4.1: potassium carbonate / acetone / 4 h / Reflux

5.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

6.1: methanol; magnesium / 5 h / Reflux

7.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 62 h / Reflux

8.1: hydrogenchloride / water; diethyl ether / 16 h / 20 °C

With hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; sodium hydroxide; In diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; acetonitrile;