diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate
CAS No.:146698-36-4
Molecular Formula:C₁₉H₂₀F₄N₂O₅
Molecular Weight:432.372
Hs Code.:

Synonyms:diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

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Chemical Property of diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

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Technology Process of diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

There total 3 articles about diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

: 106-96-7
propargyl bromide

: 146698-35-3
diethyl N-(4-amino-2,3,5,6-tetrafluorobenzoyl)-L-glutamate

: 146698-36-4
diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Guidance literature:: With caesium carbonate; In toluene; acetonitrile; at 80 ℃; for 3h;
DOI:10.1016/S0022-1139(00)82191-0

Reference yield:

: 944-43-4
4-amino-2,3,5,6-tetrafluorobenzoic acid

: 146698-36-4
diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / toluene / 3 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 25 °C

3: 31.5 percent / Cs₂CO₃ / toluene; acetonitrile / 3 h / 80 °C

With thionyl chloride; caesium carbonate; triethylamine; In dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0022-1139(00)82191-0

Reference yield:

: 146698-38-6
2,3,5,6-tetrafluoro-4-sulfinylaminobenzoyl chloride

: 146698-36-4
diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1 h / 25 °C

2: 31.5 percent / Cs₂CO₃ / toluene; acetonitrile / 3 h / 80 °C

With caesium carbonate; triethylamine; In dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0022-1139(00)82191-0