(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Base Information

Chemical Name:(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester
CAS No.:526222-98-0
Molecular Formula:C₂₉H₃₉N₃O₁₀
Molecular Weight:589.643
Hs Code.:

Synonyms:(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

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Chemical Property of (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

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Technology Process of (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

There total 5 articles about (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64187-47-9
1-benzyloxycarbonyl-4-keto-L-proline

: 526222-98-0
(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / dichloromethane / 12 h / Cooling with ice

2: water; ethanol / 72 h / Sealed tube

3: dmap / tetrahydrofuran / 12 h

With dmap; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; water; 2: |Bucherer-Bergs Reaction;
DOI:10.1016/j.tetlet.2016.09.032

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 526222-96-8
(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

: 526222-98-0
(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Guidance literature:: With dmap; In tetrahydrofuran; for 1.5h;
DOI:10.1021/ja0293958

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 526222-98-0
(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Jones reagent / acetone / 12 h / Cooling with ice

2: sulfuric acid / dichloromethane / 12 h / Cooling with ice

3: water; ethanol / 72 h / Sealed tube

4: dmap / tetrahydrofuran / 12 h

With dmap; Jones reagent; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 1: |Jones Oxidation / 3: |Bucherer-Bergs Reaction;
DOI:10.1016/j.tetlet.2016.09.032