1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4S)-

Base Information

Chemical Name:1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4S)-
CAS No.:526223-01-8
Molecular Formula:C34H36N2O8
Molecular Weight:600.668
Hs Code.:
Mol file:526223-01-8.mol

1,2,4-Pyrrolidinetricarboxylic acid,
4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl)
4-methyl 1-(phenylmethyl) ester, (2S,4S)-

Synonyms:

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Chemical Property of 1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4S)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4S)-

There total 6 articles about 1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 526222-99-1
(3S,5S)-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)-3-aminopyrrolidine-3-carboxylic acid

: 526223-01-8
(2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:

Reference yield:

: 67-56-1
methanol

: 526223-00-7
(2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 526223-01-8
(2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ja0293958

Reference yield:

: 526222-96-8
(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

: 526223-01-8
(2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP / tetrahydrofuran / 1.5 h

2: 8.24 g / aq. KOH / tetrahydrofuran / 0.42 h / 20 °C

3: diisopropylethylamine / CH₂Cl₂ / 1.5 h / 20 °C / Heating

4: diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

5: aq. HCl / ethyl acetate / pH 2

6: 2.2 g / DMAP; DCC / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; dmap; potassium hydroxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja0293958