Technology Process of 1-benzyloxy-2-fluoro-2-phenylpropane
There total 7 articles about 1-benzyloxy-2-fluoro-2-phenylpropane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: 60 percent / S-PPL enzyme, phosphate buffer, aq. NaOH / 21 h / Ambient temperature
2: 1.) (COCl)2, DMF, 2.) NaBH4 / 2.) -78 deg C, 3 h
3: 58 percent / NaH / dimethylformamide / 2 h / Ambient temperature
4: 61 percent / NaBH4 / dimethylsulfoxide / 3 h / 110 °C
5: 95 percent / Et3N, DMAP / CH2Cl2 / 3 h / Ambient temperature
6: 68 percent / NaBH4 / dimethylsulfoxide / 5 h / 150 °C
With
dmap; sodium hydroxide; sodium tetrahydroborate; phosphate buffer; oxalyl dichloride; S-PPL enzyme; sodium hydride; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(99)00088-9
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo<2.2.2>octane bis(tetrafluoroborate), NaH / tetrahydrofuran / 0.33 h / Ambient temperature
2: 60 percent / S-PPL enzyme, phosphate buffer, aq. NaOH / 21 h / Ambient temperature
3: 1.) (COCl)2, DMF, 2.) NaBH4 / 2.) -78 deg C, 3 h
4: 58 percent / NaH / dimethylformamide / 2 h / Ambient temperature
5: 61 percent / NaBH4 / dimethylsulfoxide / 3 h / 110 °C
6: 95 percent / Et3N, DMAP / CH2Cl2 / 3 h / Ambient temperature
7: 68 percent / NaBH4 / dimethylsulfoxide / 5 h / 150 °C
With
dmap; sodium hydroxide; sodium tetrahydroborate; phosphate buffer; oxalyl dichloride; S-PPL enzyme; sodium hydride; Selectfluor; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(99)00088-9
