monoethyl 2-fluoro-2-phenylmalonate

Base Information

Chemical Name:monoethyl 2-fluoro-2-phenylmalonate
CAS No.:211506-10-4
Molecular Formula:C₁₁H₁₁FO₄
Molecular Weight:226.204
Hs Code.:

Synonyms:

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Chemical Property of monoethyl 2-fluoro-2-phenylmalonate

Chemical Property:

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Technology Process of monoethyl 2-fluoro-2-phenylmalonate

There total 2 articles about monoethyl 2-fluoro-2-phenylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2802-98-4
diethyl 2-fluoro-2-phenylmalonate

: 211506-10-4
monoethyl 2-fluoro-2-phenylmalonate

Guidance literature:: With lipase S-PPL; for 21h; Ambient temperature; 0.01 M phosphate buffer pH 7;
DOI:10.1016/S0957-4166(98)00181-5

Reference yield:

: 83-13-6
diethyl 2-phenylmalonate

: 211506-10-4
monoethyl 2-fluoro-2-phenylmalonate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo<2.2.2>octane bis(tetrafluoroborate), NaH / tetrahydrofuran / 0.33 h / Ambient temperature

2: 60 percent / S-PPL enzyme, phosphate buffer, aq. NaOH / 21 h / Ambient temperature

With sodium hydroxide; phosphate buffer; S-PPL enzyme; sodium hydride; Selectfluor; In tetrahydrofuran;
DOI:10.1016/S0957-4166(99)00088-9

Reference yield:

: 211506-10-4
monoethyl 2-fluoro-2-phenylmalonate

: (S)-(+)-2-fluoro-2-phenyl-1-propanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl)2, DMF, 2.) NaBH₄ / 2.) -78 deg C, 3 h

2: 58 percent / NaH / dimethylformamide / 2 h / Ambient temperature

3: 61 percent / NaBH₄ / dimethylsulfoxide / 3 h / 110 °C

4: 95 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

5: 68 percent / NaBH₄ / dimethylsulfoxide / 5 h / 150 °C

6: 50 percent / H₂, CaCO₃ / 10 percent Pd/C / methanol / 7 h / 760 Torr / Ambient temperature

With dmap; sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium hydride; triethylamine; N,N-dimethyl-formamide; calcium carbonate; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(99)00088-9