(2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

Base Information

Chemical Name:(2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate
CAS No.:1403479-58-2
Molecular Formula:C₄₂H₅₁FN₄O₉S₂
Molecular Weight:839.019
Hs Code.:

(2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

Synonyms:(2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

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Chemical Property of (2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

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Technology Process of (2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

There total 10 articles about (2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1255397-71-7
3-[(2S,8R,9R)-11-((S)-1-hydroxypropan-2-yl)-2,9-dimethyl-8-[(N-methyl(4-fluorobenzene)sulfonamido)methyl]-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxaazacyclotetradecin-14-yl]-1-phenylurea

: 98-59-9
p-toluenesulfonyl chloride

: 1403479-58-2
(2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1255214-08-4
allyl (((2S,8R,9R)-14-((((9H-fIuoren-9-yl)methoxy)carbonyl)amino)-11-((S)-1-hydroxypropan-2-yl)-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)(methyl)carbamate

: 1403479-58-2
(2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: piperidine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

4: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

6: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

7: dmap; triethylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

With piperidine; pyridine; 2,6-dimethylpyridine; dmap; 1,3-dimethylbarbituric acid; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1353557-59-1
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

: 1403479-58-2
(2S)-2-[(2S,8R,9R)-2,9-dimethyl-8-{[N-methyl(4-fluorobenzene)sulfonamido]methyl}-12-oxo-14-[(phenylcarbamoyl)amino]-2,3,4,5,6,8,9,10,11,12-decahydro-1,7,11-benzodioxazacyclotetradecin-11-yl]propyl 4-methylbenzene-1-sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C / Inert atmosphere

4: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

6: dmap; triethylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

With piperidine; 2,6-dimethylpyridine; dmap; 1,3-dimethylbarbituric acid; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;