(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Base Information

Chemical Name:(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate
CAS No.:1353557-59-1
Molecular Formula:C₄₈H₅₅N₃O₉
Molecular Weight:817.979
Hs Code.:

(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Synonyms:(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

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Chemical Property of (S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

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Technology Process of (S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

There total 1 articles about (S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1255214-08-4
allyl (((2S,8R,9R)-14-((((9H-fIuoren-9-yl)methoxy)carbonyl)amino)-11-((S)-1-hydroxypropan-2-yl)-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)(methyl)carbamate

: 98-88-4
benzoyl chloride

: 1353557-59-1
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ml200244k

Reference yield: 60.0%

: 1353557-59-1
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

: 103-71-9
phenyl isocyanate

: 1353557-61-5
(S)-2-((2S,8R,9R)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

Guidance literature:: (S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate; With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h; Inert atmosphere;

phenyl isocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/ml200244k

Reference yield:

: 1353557-59-1
(S)-2-((2S,8R,9R)-14-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-8-((((allyloxy)carbonyl)(methyl)amino)methyl)-2,9-dimethyl-12-oxo-3,4,5,6,9,10-hexahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-11(2H,8H,12H)-yl)propyl benzoate

: C₄₄H₅₁N₃O₇

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml200244k