(3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one

Base Information

Chemical Name:(3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one
CAS No.:135556-98-8
Molecular Formula:C₁₇H₃₁NO₃Si
Molecular Weight:325.524
Hs Code.:

Synonyms:(3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one

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Chemical Property of (3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one

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Technology Process of (3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one

There total 11 articles about (3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 144069-72-7
(3S,4R)-3-<(1R)-1-(tert-Butyldimethylsiloxy)ethyl>-4-phenylsulfinylazetidin-2-one

: 135297-16-4,135556-98-8
(3S,4R)-3-<(1R)-1-tert-butyldimethylsiloxyethyl>-4-(2-oxocyclohexyl)azetidin-2-one

Guidance literature:: zinc(II) iodide; In acetonitrile; for 24h; Ambient temperature;

Reference yield: 55.0%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 86978-81-6
(3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-1-trimethylsilyl-2-azetidinone

: 135297-16-4
(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((R)-2-oxo-cyclohexyl)-azetidin-2-one

: 135556-98-8
(3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one

Guidance literature:: With tin(IV) chloride; In acetonitrile; for 1h; Yields of byproduct given;
DOI:10.1039/a605081f

Reference yield:

: 76899-07-5,78963-47-0,78963-48-1,78963-60-7,80951-41-3,81275-02-7,85647-75-2,85954-95-6,92217-74-8,104527-11-9,76855-69-1
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one

: 135556-98-8
(3S,4R)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((1S)-2-oxocyclohexyl)-azetidine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: Pd(PPh₃)4; PPh₃; Et₃N / HCOOH / CH₂Cl₂

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; triethylamine; triphenylphosphine; formic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(02)00061-6