135297-16-4

Basic information

• Product Name: (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((R)-2-oxo-cyclohexyl)-azetidin-2-one
• Synonyms: (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((R)-2-oxo-cyclohexyl)-azetidin-2-one
• CAS NO: 135297-16-4
• Molecular Weight: 325.524
• Mol File: 135297-16-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((R)-2-oxo-cyclohexyl)-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((R)-2-oxo-cyclohexyl)-azetidin-2-one(135297-16-4)
• EPA Substance Registry System: (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((R)-2-oxo-cyclohexyl)-azetidin-2-one(135297-16-4)

Safety Data

• Hazardous Substances Data: 135297-16-4(Hazardous Substances Data)

Upstream product

• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 76899-07-5 (3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one 
• 86978-81-6 (3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-1-trimethylsilyl-2-azetidinone 
• 219603-21-1 C₁₇H₁₉NO₄ 
• 219603-22-2 C₁₆H₂₃NO₃ 
• 219603-18-6 C₁₇H₂₇NO₃ 
• 219603-25-5 C₁₇H₂₇NO₃ 
• 219603-24-4 C₁₆H₂₅NO₃ 
• 219603-14-2 C₁₇H₁₉N₃O₄ 
• 219603-19-7 Carbonic acid benzyl ester (R)-1-[(3S,4R)-2-oxo-4-((R)-2-oxo-cyclohexyl)-azetidin-3-yl]-ethyl ester 
• 219603-13-1 C₁₇H₂₁NO₄ 
• 219603-26-6 C₁₇H₂₅NO₃ 
• 932-30-9 2-Hydroxybenzylamine 
• 14783-46-1 3,4-dihydro-spiro[benzo[e][1,3]oxazine-2,1'-cyclohexane] 

Downstream Products

• 158961-84-3 (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(S)-cyclohex-2-enyl-azetidin-2-one 
• 190974-40-4 [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-((1R,3S)-3-hydroxymethyl-2-oxo-cyclohexyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid allyl ester 
• 190974-26-6 [(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((R)-2-oxo-cyclohexyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid allyl ester 
• 136279-85-1 [(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((R)-2-oxo-cyclohexyl)-azetidin-1-yl]-oxo-acetic acid allyl ester 
• 190974-25-5 [(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((R)-2-oxo-cyclohexyl)-azetidin-1-yl]-hydroxy-acetic acid allyl ester 
• 135297-03-9 (3S,4R)-3-<(1R)-1-(tert-Butyldimethylsilyloxy)ethyl>-4-<(3'S)-cyclohex-1'-en-3'-yl>azetidin-2-one 

Relevant articles and documents

Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.

Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and devel

Synthesis and NMR studies of key intermediates to a new class of β-lactam: The trinems

An efficient synthesis of the four isomeric epoxides 4a-d, key compounds to the trinem ring system, starting from (3R,4R,1′R)-(+)-4-acetoxy-3-[1′-(tert-butyldimethylsilyloxy)ethyl] azetidin-2-one 6a is described. All the intermediates have been characteri

Copper-assisted substitution reaction for phenylthio group of a 4- phenylthioazetidinone derivative

The phenylthio group of 4-phenylthioazetidinone (1) was readily substituted with copper(I) salts of carboxylates, thiocarboxylates, and copper(I) enolates of malonates and β-ketoesters to give synthetic intermediates (3 and 4) for penem and carbapenem antibiotics.