3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione

Base Information

• Chemical Name: 3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione
• CAS No.: 25998-60-1
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 25998-60-1.mol

Synonyms:3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione

Chemical Property of 3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione

There total 3 articles about 3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-phenylmaleimide (83-25-0) + pivalaldehyde (630-19-3) → 3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione (25998-60-1)

Guidance literature:

With di-tert-butyl peroxide; In 1,2-dichloro-benzene; at 130 ℃; for 12h; Sealed tube;

DOI:10.1016/j.tetlet.2018.06.042

Reference yield:

N-phenyl-maleimide (941-69-5) + Isobutane (75-28-5,40921-86-6) → 3-isobutyl-1-phenyl-pyrrolidine-2,5-dione + 3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione (25998-60-1)

Guidance literature:

With tetrakis(tetrabutylammonium)decatungstate(VI); In water; acetonitrile; at 20 ℃; for 4h; under 7500.75 Torr; Overall yield = 90 percent; UV-irradiation; Flow reactor;

DOI:10.1126/science.abb4688

Reference yield:

N-phenyl-maleimide (941-69-5) + Trimethylacetic acid (75-98-9) → N-phenylmaleimide (83-25-0) + 3-(tert-butyl)-1-phenylpyrrolidine-2,5-dione (25998-60-1)

Guidance literature:

With titanium(IV) oxide; In acetonitrile; for 18h; UV-irradiation; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo4027929

upstream raw materials:

N-phenyl-maleimide

Trimethylacetic acid

N-phenylmaleimide

pivalaldehyde