[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane
CAS No.:915954-71-1
Molecular Formula:C₅₆H₅₈O₇Si
Molecular Weight:871.158
Hs Code.:

[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-<i>tert</i>-butyl-dimethyl-silane

Synonyms:[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

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Technology Process of [5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

There total 10 articles about [5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

: 915954-70-0
[2-(3,5-bis-benzyloxy-2-iodo-phenoxy)-1-bromomethyl-2-(3,4,5-tris-benzyloxy-phenyl)-ethoxy]-tert-butyl-dimethyl-silane

: 915954-71-1
[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; phenyllithium; phenylmagnesium bromide; In various solvents; at -78 ℃; for 1h;
DOI:10.1246/cl.2006.1006

Reference yield: 13.0%

: 915954-70-0
[2-(3,5-bis-benzyloxy-2-iodo-phenoxy)-1-bromomethyl-2-(3,4,5-tris-benzyloxy-phenyl)-ethoxy]-tert-butyl-dimethyl-silane

: [2-(3,5-bis-benzyloxy-phenoxy)-1-methyl-2-(3,4,5-tris-benzyloxy-phenyl)-ethoxy]-tert-butyl-dimethyl-silane

: 915954-71-1
[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: [2-(3,5-bis-benzyloxy-2-iodo-phenoxy)-1-bromomethyl-2-(3,4,5-tris-benzyloxy-phenyl)-ethoxy]-tert-butyl-dimethyl-silane; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;

With deuteromethanol; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1246/cl.2006.1006

Reference yield:

: (E)-methyl 3-(3,4,5-tris(benzyloxy)phenyl)acrylate

: 915954-71-1
[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminum hydride / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 96 percent / aq. Rochelle's salt / tetrahydrofuran; hexane; methanol / 3 h / 0 °C

2.1: 92 percent / K₃Fe(CN)6; MeSO₂NH₂; K₂CO₃ / (DHQD)2-PHAL; K₂OsO₂(OH)2 / 2-methyl-propan-2-ol; H₂O / 40.5 h / 0 °C

3.1: 89 percent / pyridine / 18 h / 0 °C

4.1: 90 percent / K₂CO₃ / methanol; dioxane / 1.5 h / 0 °C

5.1: 93 percent / TMAD; n-Bu₃P / toluene / 10 h / 0 °C

6.1: 93 percent / Li₂NiBr₄ / tetrahydrofuran / 8 h / 0 °C

7.1: 93 percent / 2,6-di-t-butylpyridine / CH₂Cl₂ / 1 h / 0 °C

8.1: tBuLi / tetrahydrofuran / -78 °C

8.2: 53 percent / CH₃OD / tetrahydrofuran / -78 - 0 °C

With pyridine; 2,6-di-tert-butyl-pyridine; tributylphosphine; methanesulfonamide; dilithium tetrabromonickelate(II); diamide; tert.-butyl lithium; diisobutylaluminium hydride; potassium carbonate; potassium hexacyanoferrate(III); K₂OsO₂(OH)2; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1246/cl.2006.1006