5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide

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Chemical Name:5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide
CAS No.:1026950-89-9
Molecular Formula:C₁₈H₁₉ClF₃N₃O₄
Molecular Weight:433.815
Hs Code.:

Synonyms:5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide

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Chemical Property of 5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide

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Technology Process of 5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide

There total 5 articles about 5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 169451-91-6
4-cyclopropylcarbonylamino-5-chloro-2-methoxybenzoic acid

: (3R)-1-(trifluoroacetyl)pyrrolidin-3-amine hydrochloride

: 1026950-89-9
5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm9601720

Reference yield:

: 20896-27-9
methyl 4-amino-5-chloro-2-methoxybenzoate

: 1026950-89-9
5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / pyridine / CH₂Cl₂ / 4 h / Ambient temperature

2: 94 percent / 2N aq. NaOH / dimethylsulfoxide / 0.5 h

3: 87 percent / Et₃N, diphenyl phosphorazidate / dimethylformamide / Ambient temperature

With pyridine; sodium hydroxide; diphenyl phosphoryl azide; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm9601720

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 1026950-89-9
5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / K₂CO₃ / dimethylsulfoxide / 4 h / Heating

2: 87 percent / pyridine / CH₂Cl₂ / 4 h / Ambient temperature

3: 94 percent / 2N aq. NaOH / dimethylsulfoxide / 0.5 h

4: 87 percent / Et₃N, diphenyl phosphorazidate / dimethylformamide / Ambient temperature

With pyridine; sodium hydroxide; diphenyl phosphoryl azide; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm9601720