methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate

Base Information

• Chemical Name: methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate
• CAS No.: 84559-78-4
• Molecular Formula: C₂₀H₃₀N₂O₆
• Molecular Weight: 394.468
• Mol file: 84559-78-4.mol

Synonyms:methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate

Chemical Property of methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate

Chemical Property:

Purity/Quality:

≥ 98% (HPLC) ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate

There total 4 articles about methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Nα-(benzyloxycarbonyl)-Nε-(tert-butoxycarbonyl)-D-lysine (66845-42-9) → methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate (84559-78-4)

Guidance literature:

In diethyl ether; ethanol; at 0 ℃; for 0.5h;

DOI:10.1021/jo00233a006

Reference yield: 73.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Nε-(tert-butoxycarbonyl)-D-lysine (31202-69-4) + benzyl chloroformate (501-53-1,94274-21-2) → methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-6-[[(tert-butoxy)carbonyl]amino]hexanoate (84559-78-4)

Guidance literature:

DOI:10.1021/jm00359a003

Reference yield:

→ Nα(1)-Benzyloxycarbonyl-Nε-tert.-butyloxycarbonyl-lysin-methylester (2389-49-3,84559-78-4)

Guidance literature:

entspr. Lasin, Diazomethan/Ae.;

upstream raw materials:

diazomethane

N_ε-(tert-butoxycarbonyl)-D-lysine

benzyl chloroformate

N^α-(benzyloxycarbonyl)-N^ε-(tert-butoxycarbonyl)-D-lysine

Downstream raw materials:

(R)-2-amino-6-tert-butoxycarbonylaminohexanoic acid methyl ester

methyl N₆-(tert-butoxycarbonyl)-D-lysinate hydrochloride

N-α-(tert-buthoxycarbonyl)-D-valylleucyl-N^ε-(tert-buthoxycarbonyl)-D-lysyl>-N',N'-bis(2-chloroethyl)-p-phenylenediamine

N-(D-valylleucyl-D-lysyl)-N',N'-bis(2-chloroethyl)-p-phenylenediamine bis(trifluoroacetate)