(S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate
CAS No.:864922-12-3
Molecular Formula:C₁₉H₃₀N₂O₅
Molecular Weight:366.458
Hs Code.:

Synonyms:(S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Suppliers and Price of (S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

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Chemical Property of (S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

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Technology Process of (S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

There total 7 articles about (S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 104-53-0
3-phenyl-propionaldehyde

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 864922-12-3
(S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: 3-phenyl-propionaldehyde; di-tert-butyl-diazodicarboxylate; With C₆₈H₇₃IrN₅O₅⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); In toluene; at 0 - 20 ℃; for 15h; Inert atmosphere; Darkness;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.25h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c4cc04636f

Reference yield: 86.0%

: 16466-61-8
1,2-bis(t-butyloxycarbonyl)hydrazine

: 122-97-4
3-Phenyl-1-propanol

: 864922-12-3
(S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: 1,2-bis(t-butyloxycarbonyl)hydrazine; 3-Phenyl-1-propanol; With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 2,6-dimethylpyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(I) bromide; In acetonitrile; at 20 ℃; for 72h;

In methanol; acetonitrile; at 0 ℃; enantioselective reaction;
DOI:10.1021/acs.orglett.6b02841

Reference yield:

: 870-50-8
di-tert-butyl (E)-azodicarboxylate

: 864922-12-3
(S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: D-proline / CH₂Cl₂ / 3 h / 20 °C

2: NaBH₄ / methanol

With sodium tetrahydroborate; D-Prolin; In methanol; dichloromethane;
DOI:10.1002/ejoc.200600502