(S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester

Base Information

• Chemical Name: (S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester
• CAS No.: 864921-99-3
• Molecular Formula: C₂₃H₃₁N₃O₆
• Molecular Weight: 445.516
• Mol file: 864921-99-3.mol

Synonyms:(S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester

Chemical Property of (S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester

There total 1 articles about (S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(E)-2-Cyano-5-phenyl-pent-2-enoic acid methyl ester + di-tert-butyl (E)-azodicarboxylate (870-50-8) → (S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester (864921-99-3)

Guidance literature:

With (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); In dichloromethane; at -24 ℃;

DOI:10.1021/ja0539847

Reference yield: 90.0%

(S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester (864921-99-3) → (4S)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpentanoic acid methyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 0 ℃; for 0.75h; under 760 Torr;

DOI:10.1021/ja0539847

Reference yield:

(S)-(E)-4-[N,N'-bis(tert-butoxycarbonyl)hydrazino]-2-cyano-5-phenylpent-2-enoic acid methyl ester (864921-99-3) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → (1S,6S)-6-{(S)-1-[N,N'-bis(tert-butoxycarbonyl)-hydrazino]-2-phenylethyl}-1-cyano-3,4-dimethylcyclohex-3-ene carboxylic acid methyl ester + (1R,6R)-6-{(S)-1-[N,N'-bis(tert-butoxycarbonyl)-hydrazino]-2-phenylethyl}-1-cyano-3,4-dimethylcyclohex-3-ene carboxylic acid methyl ester

Guidance literature:

In toluene; at 80 ℃; for 23h;

DOI:10.1021/ja0539847

upstream raw materials:

di-tert-butyl (E)-azodicarboxylate

Downstream raw materials:

(S)-di-tert-butyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate