Technology Process of 4-(2-(4-methoxyphenyl)-4-oxobutanoyl)-3-methylbenzonitrile
There total 8 articles about 4-(2-(4-methoxyphenyl)-4-oxobutanoyl)-3-methylbenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(2-(4-methoxyphenyl)pent-4-enoyl)-3-methylbenzonitrile;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 0.666667h;
With
dimethylsulfide;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2011.04.086
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide / 8 h / Reflux
2.1: water; sodium hydroxide / ethanol / 12 h / 20 °C
3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 14 h / 70 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere
4.2: -78 - 20 °C / Inert atmosphere
5.1: water; dimethyl sulfoxide / 2.5 h / 150 °C
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: -78 - 20 °C / Inert atmosphere
7.1: ozone / dichloromethane / 0.67 h / -78 °C
7.2: -78 - 20 °C
With
thionyl chloride; water; ozone; N,N-dimethyl-formamide; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.04.086
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: water; dimethyl sulfoxide / 2.5 h / 150 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: ozone / dichloromethane / 0.67 h / -78 °C
3.2: -78 - 20 °C
With
ozone; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.04.086
