N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

Base Information

Chemical Name:N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine
CAS No.:263715-09-9
Molecular Formula:C₃₄H₄₁N₆O₉P
Molecular Weight:708.708
Hs Code.:

Synonyms:N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

Chemical Property:

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Technology Process of N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

There total 5 articles about N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

: 263715-09-9
N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

Guidance literature:: With acetic acid; at 20 ℃;
DOI:10.1021/jo0000877

Reference yield:

: 2140-11-6
2',3'-O-isopropylideneinosine

: 263715-09-9
N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / pyridine / 40 h / 20 °C

2: 90 percent / K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

3: 74 percent / dimethylformamide / 21 h / 50 °C

4: 100 percent / K₂CO₃ / dimethylformamide / 50 °C

5: 85 percent / tetrazole / pyridine / 20 °C

6: 94 percent / aq. AcOH / 20 °C

With 1H-tetrazole; potassium carbonate; acetic acid; In pyridine; N,N-dimethyl-formamide; 1: Alkylation / 2: Substitution / 3: Ring cleavage / 4: Cyclization / 5: Substitution / 6: detritylation;
DOI:10.1021/jo0000877

Reference yield:

: 239080-21-8
N-1-(2,4-dinitrophenyl)-5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

: 263715-09-9
N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[[(dianilinophosphoryl)oxy]methyl]cyclopentyl]-2',3'-O-isopropylideneinosine

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / dimethylformamide / 21 h / 50 °C

2: 100 percent / K₂CO₃ / dimethylformamide / 50 °C

3: 85 percent / tetrazole / pyridine / 20 °C

4: 94 percent / aq. AcOH / 20 °C

With 1H-tetrazole; potassium carbonate; acetic acid; In pyridine; N,N-dimethyl-formamide; 1: Ring cleavage / 2: Cyclization / 3: Substitution / 4: detritylation;
DOI:10.1021/jo0000877