5-(4-methoxyphenyl)-2-(2-thienyl)pyridine

Base Information

• Chemical Name: 5-(4-methoxyphenyl)-2-(2-thienyl)pyridine
• CAS No.: 1147272-02-3
• Molecular Formula: C₁₆H₁₃NOS
• Molecular Weight: 267.351
• Mol file: 1147272-02-3.mol

Synonyms:5-(4-methoxyphenyl)-2-(2-thienyl)pyridine

Chemical Property of 5-(4-methoxyphenyl)-2-(2-thienyl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methoxyphenyl)-2-(2-thienyl)pyridine

There total 2 articles about 5-(4-methoxyphenyl)-2-(2-thienyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C14H11N3OS (1147271-99-5) + bicyclo[2.2.1]hepta-2,5-diene (121-46-0) → 5-(4-methoxyphenyl)-2-(2-thienyl)pyridine (1147272-02-3)

Guidance literature:

With o-xylene; for 48h; Reflux;

DOI:10.1016/j.tetlet.2012.07.090

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 5-(4-methoxyphenyl)-2-(2-thienyl)pyridine (1147272-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic acid; ethanol / 10 h / Reflux

2: o-xylene / 48 h / Reflux

With o-xylene; sodium acetate; In ethanol; acetic acid;

DOI:10.1016/j.tetlet.2012.07.090

Reference yield: 71.0%

potassium tetrachloroplatinate(II) (10025-99-7) + 5-(4-methoxyphenyl)-2-(2-thienyl)pyridine (1147272-02-3) + dimethyl sulfoxide (67-68-5,8070-53-9) → [Pt(5-(4-methoxyphenyl)-2-(2-thienyl)pyridine(1-))Cl(dimethylsulfoxide)] (1147272-07-8)

Guidance literature:

In water; acetic acid; to soln. ligand in AcOH aq. soln. K2(PtCl4) was added and heated to 70°C for 24 h under N2 atm., ppt. was filtered off, washed with AcOH and EtOH and dried in vacuo, DMSO was added and heated under reflux for 10 min; solvent was removed in vacuo, residue was dissolved in CH2Cl2, column chromy. on silica (CH2Cl2); elem. anal.;

DOI:10.1021/ic802401j

upstream raw materials:

C₁₄H₁₁N₃OS

bicyclo[2.2.1]hepta-2,5-diene

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

[Pt(5-(4-methoxyphenyl)-2-(2-thienyl)pyridine^(1-))Cl(dimethylsulfoxide)]

[Pt(5-(4-methoxyphenyl)-2-(2-thienyl)pyridine^(1-))(acetylacetonato)]

5-(4-hydroxyphenyl)-2-(2-thienyl)pyridine

ethyl 2-(4-(6-(thiophen-2-yl)pyridin-3-yl)phenoxy)acetate