(R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride

Base Information

• Chemical Name: (R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride
• CAS No.: 1228022-09-0
• Molecular Formula: C₂₆H₂₃F₂N₅O₂*ClH
• Molecular Weight: 511.959

Synonyms:(R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride

Chemical Property of (R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride

There total 4 articles about (R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-(4-fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide (1228072-35-2) → (R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride (1228022-09-0)

Guidance literature:

With hydrogenchloride; In methanol; water;

Reference yield:

(R)-piperazin-2-ylmethanol (149715-47-9) → (R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride (1228022-09-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 64 h / 120 °C

2: dichloromethane / 0.5 h / 20 °C

3: hydrogenchloride / water; methanol

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

1-chloro-4-(4-fluorophenyl)-1-phthalazine (155937-28-3) → (R)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide hydrochloride (1228022-09-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 64 h / 120 °C

2: dichloromethane / 0.5 h / 20 °C

3: hydrogenchloride / water; methanol

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

1-chloro-4-(4-fluorophenyl)-1-phthalazine

(R)-(4-(4-(4-Fluorophenyl)phthalazin-1-yl)piperazin-2-yl)methanol

(R)-piperazin-2-ylmethanol

(R)-N-(4-fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-(hydroxymethyl)piperazine-1-carboxamide

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