methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

Base Information

Chemical Name:methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate
CAS No.:1383824-64-3
Molecular Formula:C₃₀H₂₈F₃N₃O₅S
Molecular Weight:599.631
Hs Code.:

methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

Synonyms:methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

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Chemical Property of methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

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Technology Process of methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

There total 8 articles about methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1103500-71-5
6-bromobenzo[d]isothiazole-3-carboxylic acid methyl ester

: 1383822-31-8
(1R,3S,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octane

: 1383824-64-3
methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In xylene; at 120 ℃; for 12h; Inert atmosphere;

Reference yield:

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 1383824-64-3
methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 1 h / 0 - 20 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3: potassium carbonate / tetrahydrofuran / 6 h / -10 - 35 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

5: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

6: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / xylene / 12 h / 120 °C / Inert atmosphere

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; potassium carbonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; xylene;

Reference yield:

: 946427-86-7
4-(bromomethyl)-5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole

: 1383824-64-3
methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / xylene / 12 h / 120 °C / Inert atmosphere

With 18-crown-6 ether; potassium tert-butylate; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; dichloromethane; xylene;