6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

Base Information

Chemical Name:6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid
CAS No.:1383817-89-7
Molecular Formula:C₂₉H₂₆F₃N₃O₅S
Molecular Weight:585.604
Hs Code.:

Synonyms:6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

Suppliers and Price of 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

There total 9 articles about 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383824-64-3
methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate

: 1383817-89-7
6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

Guidance literature:: methyl 6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 12h;

With sodium hydroxide; In water; pH=7; Cooling with ice;

Reference yield:

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 1383817-89-7
6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 1 h / 0 - 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3.1: potassium carbonate / tetrahydrofuran / 6 h / -10 - 35 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

6.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / xylene / 12 h / 120 °C / Inert atmosphere

9.1: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 °C

9.2: pH 7 / Cooling with ice

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; water; potassium carbonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; xylene;

Reference yield:

: 1383740-00-8
(E)-2-(trifluoromethoxy)benzaldehyde oxime

: 1383817-89-7
6-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]isothiazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

2.1: potassium carbonate / tetrahydrofuran / 6 h / -10 - 35 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

5.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / xylene / 12 h / 120 °C / Inert atmosphere

8.1: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 °C

8.2: pH 7 / Cooling with ice

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; water; potassium carbonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; xylene;