(E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid

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Chemical Name:(E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid
CAS No.:91111-91-0
Molecular Formula:C₁₈H₁₈N₄O₃
Molecular Weight:338.366
Hs Code.:

Synonyms:(E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid

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Chemical Property of (E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid

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Technology Process of (E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid

There total 5 articles about (E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 91111-90-9
(E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid ethyl ester

: 91111-91-0
(E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; for 1h; Heating;
DOI:10.1021/jm00376a003

Reference yield:

: 100-34-5
benzene diazonium chloride

: 91111-91-0
(E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 75 percent aq. AcOH / 3 h / 0 °C

2: 52 percent / dimethylsulfoxide / 24 h / Ambient temperature

3: 78 percent / KOH / ethanol; H₂O / 1 h / Heating

With potassium hydroxide; acetic acid; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00376a003

Reference yield:

: 88243-65-6
(-)-(6R)-6-methyl-6,7,8,9-tetrahydro-4H-pyrido<1,2-a>pyrimidin-4-one

: 91111-91-0
(E)-3-[(R)-6-Methyl-4-oxo-9-(phenyl-hydrazono)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / POCl₃

2: 92 percent / 75 percent aq. AcOH / 3 h / 0 °C

3: 52 percent / dimethylsulfoxide / 24 h / Ambient temperature

4: 78 percent / KOH / ethanol; H₂O / 1 h / Heating

With potassium hydroxide; acetic acid; trichlorophosphate; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00376a003