Cyclopentanone, 3-acetyl-, (3S)- (9CI)

Base Information

• Chemical Name: Cyclopentanone, 3-acetyl-, (3S)- (9CI)
• CAS No.: 155253-53-5
• Molecular Formula: C₇H₁₀O₂
• Molecular Weight: 126.155
• Mol file: 155253-53-5.mol

Synonyms:Cyclopentanone,3-acetyl-, (S)-

Chemical Property of Cyclopentanone, 3-acetyl-, (3S)- (9CI)

Chemical Property:

• Boiling Point: 221.0±33.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.083±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopentanone, 3-acetyl-, (3S)- (9CI)

There total 25 articles about Cyclopentanone, 3-acetyl-, (3S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(+/-)-4-hydroxy-4-methyl-2-cyclohexen-1-one (70150-56-0) → 3-Acetylcyclopentanone (84602-27-7,155253-53-5)

Guidance literature:

In 2,2,2-trifluoroethanol; for 52h; Irradiation; Inert atmosphere;

DOI:10.1016/j.tet.2013.09.037

Reference yield: 80.0%

3-(1'-nitroethyl)cyclopentanone (127129-72-0) → 3-Acetylcyclopentanone (84602-27-7,155253-53-5)

Guidance literature:

With sodium hydroxide; sodium chlorite; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(01)93778-5

Reference yield: 77.0%

2-methyl-2-(3-oxocyclopentyl)malonic acid → 3-Acetylcyclopentanone (84602-27-7,155253-53-5)

Guidance literature:

2-methyl-2-(3-oxocyclopentyl)malonic acid; With ammonia; In methanol; at 20 ℃; for 5h; Electrochemical reaction;

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1021/acs.joc.8b01994

upstream raw materials:

Nitroethane

cyclopent-2-enone

1-(trimethylsilyl)ethanone

acetic anhydride

Refernces

• 1、 Ma, Xiaofeng,Dewez, Damien F.,Du, Le,Luo, Xiya,Markó, István E.,Lam, Kevin. "Synthesis of Diketones, Ketoesters, and Tetraketones by Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: Application to the Synthesis of cis-Jasmone". . . Retrieved 2018/10/15.
• 2、 Tuttle, Jamison B.,Ouellet, Stephane G.,MacMillan, David W. C.. "Organocatalytic transfer hydrogenation of cyclic enones". . p. 12662 - 12663. Retrieved 2008/02/05.