C₁₉H₂₀N₂O₂

Base Information

Chemical Name:C₁₉H₂₀N₂O₂
CAS No.:289473-53-6
Molecular Formula:C₁₉H₂₀N₂O₂
Molecular Weight:308.38
Hs Code.:

C<sub>19</sub>H<sub>20</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₁₉H₂₀N₂O₂

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Chemical Property of C₁₉H₂₀N₂O₂

Chemical Property:

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Technology Process of C₁₉H₂₀N₂O₂

There total 11 articles about C₁₉H₂₀N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 289473-52-5
N-phenoxycarbonyl-6-{2-[(3-(trifluoromethylsulfonyl)oxy)-4-pyridinyl]-ethyl}-1,2,3,4-tetrahydropyridine

: 289473-53-6
C₁₉H₂₀N₂O₂

Guidance literature:: N-phenoxycarbonyl-6-{2-[(3-(trifluoromethylsulfonyl)oxy)-4-pyridinyl]-ethyl}-1,2,3,4-tetrahydropyridine; With (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; palladium diacetate; In acetonitrile; at 60 ℃; for 181h;

With hydrogen; palladium on activated charcoal; In ethanol; for 48h; under 760.051 Torr; Further stages.;
DOI:10.1021/ol006056f

Reference yield:

: 98976-94-4
N,N-diethyl-4-iodo-3-pyridyl O-carbamate

: 289473-53-6
C₁₉H₂₀N₂O₂

Guidance literature:: Multi-step reaction with 9 steps

1.1: 63 percent / NaOH; water / methanol / Heating

2.1: 59 percent / 0.5 h / 70 °C

3.1: 90 percent / CuI; triethylamine / PdCl₂(PPh₃)2 / tetrahydrofuran / 1 h / 20 °C

4.1: 54 percent / tetrabutylammonium fluoride; H₂O / tetrahydrofuran / 1 h / 20 °C

5.1: CuI; triethylamine / PdCl₂(PPh₃)2 / tetrahydrofuran / 1 h / 20 °C

6.1: 42 percent / H₂ / Pd/C; quinoline / ethyl acetate / 2 h / 20 °C / 760.05 Torr

7.1: 87 percent / NaHCO₃; H₂O / methanol / 1.5 h / 20 °C

8.1: 70 percent / triethylamine / CH₂Cl₂ / 20 °C

9.1: (R)-(+)-BINAP; triethylamine / Pd(OAc)2 / acetonitrile / 181 h / 60 °C

9.2: H₂ / Pd/C / ethanol / 48 h / 760.05 Torr

With sodium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydrogencarbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; quinoline; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile; 1.1: Hydrolysis / 2.1: Acetylation / 3.1: catalyzed coupling / 4.1: Hydrolysis / 5.1: catalyzed coupling / 6.1: Catalytic hydrogenation / 7.1: Hydrolysis / 8.1: Addition / 9.1: Cyclization / 9.2: Catalytic hydrogenation;
DOI:10.1021/ol006056f

Reference yield:

: 109-00-2
3-HYDROXYPYRIDINE

: 289473-53-6
C₁₉H₂₀N₂O₂

Guidance literature:: Multi-step reaction with 11 steps

2.1: tetramethylethylenediamine; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 76 percent / I₂ / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 63 percent / NaOH; water / methanol / Heating

4.1: 59 percent / 0.5 h / 70 °C

5.1: 90 percent / CuI; triethylamine / PdCl₂(PPh₃)2 / tetrahydrofuran / 1 h / 20 °C

6.1: 54 percent / tetrabutylammonium fluoride; H₂O / tetrahydrofuran / 1 h / 20 °C

7.1: CuI; triethylamine / PdCl₂(PPh₃)2 / tetrahydrofuran / 1 h / 20 °C

8.1: 42 percent / H₂ / Pd/C; quinoline / ethyl acetate / 2 h / 20 °C / 760.05 Torr

9.1: 87 percent / NaHCO₃; H₂O / methanol / 1.5 h / 20 °C

10.1: 70 percent / triethylamine / CH₂Cl₂ / 20 °C

11.1: (R)-(+)-BINAP; triethylamine / Pd(OAc)2 / acetonitrile / 181 h / 60 °C

11.2: H₂ / Pd/C / ethanol / 48 h / 760.05 Torr

With sodium hydroxide; copper(l) iodide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydrogencarbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; quinoline; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; acetonitrile; 1.1: Addition / 2.1: Metallation / 2.2: Iodination / 3.1: Hydrolysis / 4.1: Acetylation / 5.1: catalyzed coupling / 6.1: Hydrolysis / 7.1: catalyzed coupling / 8.1: Catalytic hydrogenation / 9.1: Hydrolysis / 10.1: Addition / 11.1: Cyclization / 11.2: Catalytic hydrogenation;
DOI:10.1021/ol006056f