(S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

Base Information

Chemical Name:(S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one
CAS No.:1615681-45-2
Molecular Formula:C₂₈H₂₁ClN₆O
Molecular Weight:492.967
Hs Code.:

Synonyms:(S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

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Chemical Property of (S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

There total 4 articles about (S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1615681-43-0
(S)-2-(1-(6-amino-5-iodopyrimidin-4-ylamino)ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

: 536-74-3
phenylacetylene

: 1615681-45-2
(S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 70 ℃; for 2h;

Reference yield:

: 1420627-35-5
(S)-2-(1-aminoethyl)-5-chloro-3-phenylquinazoline-4(3H)-one

: 1615681-45-2
(S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C / Microwave irradiation

2: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; isopropyl alcohol;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1615681-45-2
(S)-2-(1-(6-amino-5-(phenylethynyl)pyrimidin-4-ylamino)-ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / toluene / 3 h / 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 3 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.6b00213