((3R,8AS)-octahydropyrrolo[1,2-a]pyrazin-3-yl)methanol

Base Information

Chemical Name:((3R,8AS)-octahydropyrrolo[1,2-a]pyrazin-3-yl)methanol
CAS No.:155225-19-7
Molecular Formula:C₈H₁₆N₂O
Molecular Weight:156.228
Hs Code.:
DSSTox Substance ID:DTXSID401222867
Nikkaji Number:J767.573I
Mol file:155225-19-7.mol

Synonyms:155225-19-7;Pyrrolo[1,2-a]pyrazine-3-methanol, octahydro-, (3R-trans)- (9CI);((3R,8AS)-octahydropyrrolo[1,2-a]pyrazin-3-yl)methanol;[(3R,8aS)-1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2-a]pyrazin-3-yl]methanol;[(3R,8AS)-OCTAHYDROPYRROLO[1,2-A]PIPERAZIN-3-YL]METHANOL;WSHDBTQQKKWIIQ-SFYZADRCSA-N;SCHEMBL336904;(3R,8aS)-Octahydropyrrolo[1,2-a]pyrazine-3-methanol;DTXSID401222867;AKOS005264968;E73184;EN300-365281;(3R,8AS)Octahydropyrrolo[1,2-a]pyrazin-3-ylmethanol;(3R,8aS)-octahydropyrrolo[1,2-a]pyrazin-3-ylmethanol

Suppliers and Price of ((3R,8AS)-octahydropyrrolo[1,2-a]pyrazin-3-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3R,8aS)-Octahydro-pyrrolo[1,2-a]pyrazine-3-methanol
50mg
$ 175.00

AK Scientific
(3R,8As)-octahydropyrrolo[1,2-a]pyrazin-3-ylmethanol
250mg
$ 464.00

Total 2 raw suppliers

Chemical Property of ((3R,8AS)-octahydropyrrolo[1,2-a]pyrazin-3-yl)methanol

Chemical Property:

PSA：35.50000
LogP:-0.31840
XLogP3:-0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:156.126263138
Heavy Atom Count:11
Complexity:140

Purity/Quality:

99% ^*data from raw suppliers

(3R,8aS)-Octahydro-pyrrolo[1,2-a]pyrazine-3-methanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2CNC(CN2C1)CO
Isomeric SMILES:C1C[C@H]2CN[C@H](CN2C1)CO

Technology Process of ((3R,8AS)-octahydropyrrolo[1,2-a]pyrazin-3-yl)methanol

There total 5 articles about ((3R,8AS)-octahydropyrrolo[1,2-a]pyrazin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 71018-04-7
(2S,5S)-2-hydroxymethyl-3,6-diketo-1,4-diaza<4.3.0>bicyclononane

: 155225-19-7
(2R,5S)-2-hydroxymethyl-1,4-diaza<4.3.0>bicyclononane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 65 - 68 ℃; for 72h;
DOI:10.1016/0957-4166(96)00241-8

Reference yield:

: (S)-2-Ethoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid benzyl ester

: 155225-19-7
(2R,5S)-2-hydroxymethyl-1,4-diaza<4.3.0>bicyclononane

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methylmorpholine / CH₂Cl₂ / a) -15 deg C, 1 h, b) RT, 12 h

2: 10percent Pd/C, cyclohexene / methanol / 5 h / Heating

3: methanol / 110 h / 62 - 65 °C

4: 62 percent / LiAlH₄ / tetrahydrofuran / 72 h / 65 - 68 °C

With 4-methyl-morpholine; palladium on activated charcoal; lithium aluminium tetrahydride; cyclohexene; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0957-4166(96)00241-8

Reference yield:

: 2481-26-7
N--(S)-serine methylester

: 155225-19-7
(2R,5S)-2-hydroxymethyl-1,4-diaza<4.3.0>bicyclononane

Guidance literature:: Multi-step reaction with 3 steps

1: 10percent Pd/C, cyclohexene / methanol / 5 h / Heating

2: methanol / 110 h / 62 - 65 °C

3: 62 percent / LiAlH₄ / tetrahydrofuran / 72 h / 65 - 68 °C

With palladium on activated charcoal; lithium aluminium tetrahydride; cyclohexene; In tetrahydrofuran; methanol;
DOI:10.1016/0957-4166(96)00241-8